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In vitro assessment of the effect of clavulanic acid at concentrations achieved in human serum on the bactericidal activity of amoxicillin at physiological concentrations against Staphylococcus aureus: implications for dosage regimens.

The effects on Staphylococcus aureus viability and beta-lactamase activity of concentrations that simulated those in human serum after a combined dose of 875 mg of amoxicillin and 125 mg of clavulanic acid were studied in an in vitro pharmacodynamic model. Six hours of preexposure to concentrations...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Principais autores: Aguilar, L, Martín, M, Balcabao, I P, Gómez-Lus, M L, Dal-Ré, R, Prieto, J
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1997
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163926/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9174210/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.6.1403
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