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Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89.

The anabolism of 1592U89, (-)-(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclo pentene-1-methanol, a selective inhibitor of human immunodeficiency virus (HIV), was characterized in human T-lymphoblastoid CD4+ CEM cells. 1592U89 was ultimately anabolized to the triphosphate (TP) of the...

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Sparad:
I publikationen:Antimicrob Agents Chemother
Huvudupphov: Faletto, M B, Miller, W H, Garvey, E P, St Clair, M H, Daluge, S M, Good, S S
Materialtyp: Artigo
Språk:Inglês
Utgiven: American Society for Microbiology (ASM) 1997
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163857/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9145876/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.5.1099
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