Metabolism of rifabutin and its 25-desacetyl metabolite, LM565, by human liver microsomes and recombinant human cytochrome P-450 3A4: relevance to clinical interaction with fluconazole.

Rifabutin and fluconazole are often given concomitantly as therapy to prevent opportunistic infections in individuals infected with the human immunodeficiency virus. Recent reports have shown increased levels of rifabutin and its 25-desacetyl metabolite, LM565, in plasma when rifabutin is administer...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Trapnell, C B, Jamis-Dow, C, Klecker, R W, Collins, J M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163826/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9145845/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.5.924
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