Emergence of an inhibitor-resistant beta-lactamase (SHV-10) derived from an SHV-5 variant.

An inhibitor-resistant beta-lactamase (SHV-10), derived from an SHV-5 variant (SHV-9), was found in an Escherichia coli clinical isolate. In SHV-10, Ser-130 was replaced by Gly. The enzyme partially retained its ability to hydrolyze penicillins, but its activity against cephalosporins was drasticall...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Prinarakis, E E, Miriagou, V, Tzelepi, E, Gazouli, M, Tzouvelekis, L S
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1997
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163805/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9087500/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.4.838
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