Amphotericin B protects cis-parinaric acid against peroxyl radical-induced oxidation: amphotericin B as an antioxidant.

The antifungal effects of amphotericin B are believed to be due to two possibly interrelated mechanisms: an increase in permeation by binding to sterols in cellular membranes and a prooxidant effect causing oxidative damage in target cells. However, the seven conjugated double bonds in amphotericin...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Osaka, K, Ritov, V B, Bernardo, J F, Branch, R A, Kagan, V E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9087481/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.4.743
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