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Importance of beta-lactamase inhibitor pharmacokinetics in the pharmacodynamics of inhibitor-drug combinations: studies with piperacillin-tazobactam and piperacillin-sulbactam.

An in vitro pharmacokinetic model was used to study the pharmacodynamics of piperacillin-tazobactam and piperacillin-sulbactam against gram-negative bacilli producing plasmid-encoded beta-lactamases. Logarithmic-phase cultures were exposed to peak antibiotic concentrations observed in human serum af...

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書目詳細資料
發表在:Antimicrob Agents Chemother
Principais autores: Lister, P D, Prevan, A M, Sanders, C C
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 1997
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在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163782/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9087477/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.4.721
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