A PCR-oligonucleotide ligation assay to determine the prevalence of 23S rRNA gene mutations in clarithromycin-resistant Helicobacter pylori.

We have developed a rapid PCR-oligonucleotide ligation assay that can discriminate single base substitutions that are associated with clarithromycin resistance in Helicobacter pylori. Susceptible isolates were wild type at positions 2143 and 2144 (cognate to 2058 and 2059 in Escherichia coli), while...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Stone, G G, Shortridge, D, Versalovic, J, Beyer, J, Flamm, R K, Graham, D Y, Ghoneim, A T, Tanaka, S K
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163779/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9056021/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.3.712
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