Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones.

gyrA and parC mutations have been identified inn Streptococcus pneumoniae mutants stepwise selected for resistance to sparfloxacin, an antipneumococcal fluoroquinolone. GyrA mutations (at the position equivalent to resistance hot spot Ser-83 in Escherichia coli GyrA) were found in all 17 first-step...

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Bibliografiset tiedot

Julkaisussa:	Antimicrob Agents Chemother
Päätekijät:	Pan, X S, Fisher, L M
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Microbiology (ASM) 1997
Aiheet:	Research Article
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163733/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9021211/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.2.471
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