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DNA Damage-Induced Cell Cycle Regulation and Function of Novel Chk2 Phosphoresidues
Chk2 kinase is activated by DNA damage to regulate cell cycle arrest, DNA repair, and apoptosis. Phosphorylation of Chk2 in vivo by ataxia telangiectasia-mutated (ATM) on threonine 68 (T68) initiates a phosphorylation cascade that promotes the full activity of Chk2. We identified three serine residu...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1636737/ https://ncbi.nlm.nih.gov/pubmed/16940182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00534-06 |
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