DNA Damage-Induced Cell Cycle Regulation and Function of Novel Chk2 Phosphoresidues

Chk2 kinase is activated by DNA damage to regulate cell cycle arrest, DNA repair, and apoptosis. Phosphorylation of Chk2 in vivo by ataxia telangiectasia-mutated (ATM) on threonine 68 (T68) initiates a phosphorylation cascade that promotes the full activity of Chk2. We identified three serine residu...

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Bibliographic Details
Main Authors: Buscemi, Giacomo, Carlessi, Luigi, Zannini, Laura, Lisanti, Sofia, Fontanella, Enrico, Canevari, Silvana, Delia, Domenico
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636737/
https://ncbi.nlm.nih.gov/pubmed/16940182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00534-06
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