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Transgene Insertion in Proximity to thec-myb Gene Disrupts Erythroid-Megakaryocytic Lineage Bifurcation

The nuclear proto-oncogene c-myb plays crucial roles in the growth, survival, and differentiation of hematopoietic cells. We established three lines of erythropoietin receptor-transgenic mice and found that one of them exhibited anemia, thrombocythemia, and splenomegaly. These abnormalities were ind...

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מידע ביבליוגרפי
Main Authors: Mukai, Harumi Y., Motohashi, Hozumi, Ohneda, Osamu, Suzuki, Norio, Nagano, Masumi, Yamamoto, Masayuki
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2006
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636724/
https://ncbi.nlm.nih.gov/pubmed/16940183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00718-06
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