Millimeter-scale positioning of a nerve-growth-factor source and biological activity in the brain

Toxicity prevents the systemic administration of many therapeutic proteins, and attempts at protein targeting via the circulatory system (i.e., “magic bullets”) have failed in all but a few special cases. Direct administration at the target site is a logical alternative, particularly in the central...

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Bibliographic Details
Main Authors: Mahoney, Melissa J., Saltzman, W. Mark
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC16367/
https://ncbi.nlm.nih.gov/pubmed/10200297
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