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JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila

Loss of the epithelial polarity gene scribble in clones of Drosophila imaginal disc cells can cooperate with Ras signaling to induce malignant tumors. Such mutant tissue overproliferates, resists apoptosis, leaves its place of origin and invades other organs, ultimately causing lethality. We show th...

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Detalhes bibliográficos
Main Authors: Uhlirova, Mirka, Bohmann, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636619/
https://ncbi.nlm.nih.gov/pubmed/17082773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601401
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