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Correlation of trimethoprim and brodimoprim physicochemical and lipid membrane interaction properties with their accumulation in human neutrophils.

Dipalmitoylphosphatidylcholine vesicles were used as a biological membrane model to investigate the interaction and the permeation properties of trimethoprim and brodimoprim as a function of drug protonation. The drug-membrane interaction was studied by differential scanning calorimetry. Both drugs...

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Detalhes bibliográficos
Main Authors: Fresta, M, Furneri, P M, Mezzasalma, E, Nicolosi, V M, Puglisi, G
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC163637/
https://ncbi.nlm.nih.gov/pubmed/9124856
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