Pharmacokinetics of KRM-1648, a new benzoxazinorifamycin, in rats and dogs.

The pharmacokinetics of 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl) benzoxazinorifamycin (KRM-1648) in rats and dogs given a single oral dose of 3, 30, or 100 mg/kg of body weight were studied. In the rats, the concentrations of KRM-1648 in plasma, whole blood, and tissues peaked between 2.0...

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Main Authors: Hosoe, K, Mae, T, Konishi, E, Fujii, K, Yamashita, K, Yamane, T, Hidaka, T, Ohashi, T
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1996
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC163615/
https://ncbi.nlm.nih.gov/pubmed/9124834
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