Impaired growth and neurological abnormalities in branched-chain α-keto acid dehydrogenase kinase-deficient mice

The BCKDH (branched-chain α-keto acid dehydrogenase complex) catalyses the rate-limiting step in the oxidation of BCAAs (branched-chain amino acids). Activity of the complex is regulated by a specific kinase, BDK (BCKDH kinase), which causes inactivation, and a phosphatase, BDP (BCKDH phosphatase),...

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Main Authors: Joshi, Mandar A., Jeoung, Nam Ho, Obayashi, Mariko, Hattab, Eyas M., Brocken, Eric G., Liechty, Edward A., Kubek, Michael J., Vattem, Krishna M., Wek, Ronald C., Harris, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2006
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635446/
https://ncbi.nlm.nih.gov/pubmed/16875466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060869
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