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Top3 Processes Recombination Intermediates and Modulates Checkpoint Activity after DNA Damage
Mutation of TOP3 in Saccharomyces cerevisiae causes poor growth, hyperrecombination, and a failure to fully activate DNA damage checkpoints in S phase. Here, we report that overexpression of a dominant-negative allele of TOP3, TOP3(Y356F), which lacks the catalytic (decatenation) activity of Top3, c...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Cell Biology
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1635375/ https://ncbi.nlm.nih.gov/pubmed/16899506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-06-0516 |
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