Inhibition of peptidoglycan biosynthesis in vancomycin-susceptible and -resistant bacteria by a semisynthetic glycopeptide antibiotic.

LY191145 is a p-chlorobenzyl derivative of LY264826 (A82846B) with activity against both vancomycin-susceptible and -resistant enterococci. Incorporation of L-[14C]lysine into peptidoglycan of intact vancomycin-susceptible and -resistant Enterococcus faecium was inhibited by LY191145 (50% inhibitory...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Allen, N E, Hobbs, J N, Nicas, T I
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163534/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8891144/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.10.2356
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