Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys.

(-)-beta-D-2-Aminopurine dioxolane (APD) and (-)-beta-D-2-amino-6-chloropurine dioxolane (ACPD) are recently synthesized dioxolanylpurine nucleoside derivatives being developed as potential prodrugs for the antiviral nucleoside analog (-)-beta-D-dioxolane guanine (DXG). In vitro, APD and ACPD are co...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Chen, H, Boudinot, F D, Chu, C K, Mcclure, H M, Schinazi, R F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163530/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8891140/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.10.2332
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