A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3

Achondroplasia, the most common form of dwarfism in man, is a dominant genetic disorder caused by a point mutation (G380R) in the transmembrane region of fibroblast growth factor receptor 3 (FGFR3). We used gene targeting to introduce the human achondroplasia mutation into the murine FGFR3 gene. Het...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wang, Yingcai, Spatz, Michal K., Kannan, Karuppiah, Hayk, Hovhannisyan, Avivi, Aaron, Gorivodsky, Marat, Pines, Mark, Yayon, Avner, Lonai, Peter, Givol, David
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16353/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10200283/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.8.4455
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