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A Synthetic Congener Modeled on a Microbicidal Domain of Thrombin- Induced Platelet Microbicidal Protein 1 Recapitulates Staphylocidal Mechanisms of the Native Molecule

Thrombin-induced platelet microbicidal protein 1 (tPMP-1) is a staphylocidal peptide released by activated platelets. This peptide initiates its microbicidal activity by membrane permeabilization, with ensuing inhibition of intracellular macromolecular synthesis. RP-1 is a synthetic congener modeled...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xiong, Yan Q., Bayer, Arnold S., Elazegui, Lisa, Yeaman, Michael R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635186/
https://ncbi.nlm.nih.gov/pubmed/16954324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00038-06
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