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Differences in potential for amino acid change after mutation reveals distinct strategies for κ and λ light-chain variation
B cells generate varied yet functional clones under high rates of mutation of their V genes. It has been proposed that as a result of the opposing demands of diversification and preservation of integrity, the V genes of heavy and light chains have evolved to overexpress codons prone to amino acid ch...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1635110/ https://ncbi.nlm.nih.gov/pubmed/17038496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607581103 |
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