Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection.

N,N-dimethylglycylamido (DMG) derivatives of 6-demethyl-6-deoxytetracycline and doxycycline bind 5-fold more effectively than tetracycline to the tetracycline high-affinity binding site on the Escherichia coli 70S ribosome, which correlates with a 10-fold increase in potency for inhibition of E. col...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Bergeron, J, Ammirati, M, Danley, D, James, L, Norcia, M, Retsema, J, Strick, C A, Su, W G, Sutcliffe, J, Wondrack, L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163507/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8878615/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.9.2226
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