In vivo activity and pharmacodynamics of amoxicillin in combination with fosfomycin in fibrin clots infected with highly penicillin-resistant Streptococcus pneumoniae.

Using a clinical pneumococcal strain for which MICs were 4, 2, and 32 mg/liter for penicillin, amoxicillin, and fosfomycin, respectively, we studied the efficacies of these antibiotics alone and their combinations in the treatment of prolonged (48-h) experimental fibrin clot infection in rabbits. Tr...

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Bibliographic Details
Main Authors: Chavanet, P, Peyrard, N, Pechinot, A, Buisson, M, Duong, M, Neuwirth, C, Kazmierczak, A, Portier, H
Format: Artigo
Language:Inglês
Published: 1996
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC163473/
https://ncbi.nlm.nih.gov/pubmed/8878581
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