Mechanism of differential activities of ofloxacin enantiomers.

Ofloxacin, a potent quinolone antibacterial agent, has a tricyclic ring structure with a methyl group attached to the asymmetric carbon at the C-3 position on the oxazine ring. The S isomer (DR-3355) of ofloxacin has antibacterial activity up to 2 orders of magnitude greater than that of the R isome...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Morrissey, I, Hoshino, K, Sato, K, Yoshida, A, Hayakawa, I, Bures, M G, Shen, L L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8843280/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.8.1775
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