Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra.

To characterize mechanisms of resistance to fluoroquinolones by Mycobacterium tuberculosis, mutants of strain H37Ra were selected in vitro with ofloxacin. Their quinolone resistance-determining regions for gyrA and gyrB were amplified and sequenced to identify mutations in gyrase A or B. Three types...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Kocagöz, T, Hackbarth, C J, Unsal, I, Rosenberg, E Y, Nikaido, H, Chambers, H F
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163415/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8843279/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.8.1768
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