The nucleoside analog-resistant E89G mutant of human immunodeficiency virus type 1 reverse transcriptase displays a broader cross-resistance that extends to nonnucleoside inhibitors.
The alteration of a glutamic acid (E) to a glycine (G) amino acid residue at position 89 (E89G alteration) in the human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to several nucleoside analog inhibitors. Because the nonnucleoside inhibitor-binding pocket is...
Sparad:
| I publikationen: | Antimicrob Agents Chemother |
|---|---|
| Huvudupphov: | , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
American Society for Microbiology (ASM)
1996
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163400/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8807067/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.7.1711 |
| Taggar: |
Inga taggar, Lägg till första taggen!
|