Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays.

D0870 was 12 to 15 times more active than fluconazole in experiments to determine the MIC for growth arrest for two isolates of Candida albicans. A biochemical comparison of in vitro sterol biosynthesis in cell extracts showed only a twofold superiority of D0870 over fluconazole. A large differentia...

Full description

Saved in:
Bibliographic Details
Main Authors: Venkateswarlu, K, Denning, D W, Manning, N J, Kelly, S L
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC163335/
https://ncbi.nlm.nih.gov/pubmed/8726005
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items