6,7-disubstituted 2,4-diaminopteridines: novel inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.

Four novel, disubstituted diaminopteridines have been identified which antagonize the uptake of a folate precursor (para-aminobenzoic acid) by rat-derived Pneumocystis carinii maintained in short-term axenic culture at concentrations ranging from 4.5 to 26 microM. The compounds were at least 10 to 1...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Jackson, H C, Biggadike, K, McKilligin, E, Kinsman, O S, Queener, S F, Lane, A, Smith, J E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163333/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8726003/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.6.1371
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