In vivo antibacterial effects of simulated human serum profiles of once-daily versus thrice-daily dosing of amikacin in a Serratia marcescens endocarditis experimental model.
Once-daily dosage of aminoglycosides is currently under consideration. The lower toxicity of this regimen has been clearly established, but there are conflicting experimental and clinical data concerning its efficacy. It is inadvisable to optimize human therapy by extrapolation from experimental stu...
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| Udgivet i: | Antimicrob Agents Chemother |
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| Principais autores: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1996
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163284/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8723459/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.5.1164 |
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