Inhibition of 2,3-oxidosqualene-lanosterol cyclase in Candida albicans by pyridinium ion-based inhibitors.

The N-(4E,8E)-5,9,13-trimethyl-4,8,12-tetradecatrien-1- ylpyridinium and N-(4E,8E)-5,9,13-trimethyl-4,8,12-tetradecatrien-1- ylpicolinium cations were evaluated for their ability to inhibit 2,3-oxidosqualene-lanosterol cyclase activity in Candida albicans. Both compounds inhibited fungal growth, wer...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Goldman, R C, Zakula, D, Capobianco, J O, Sharpe, B A, Griffin, J H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163259/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8849227/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.4.1044
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