In vitro bactericidal and in vivo therapeutic activities of a new rifamycin derivative, KRM-1648, against Mycobacterium tuberculosis.

The in vitro and in vivo activities of a new rifamycin derivative, KRM-1648, against Mycobacterium tuberculosis H37Rv were compared with those of rifampin. Bactericidal activity was evaluated by using a silicone-coated slide culture method. The MBC of KRM-1648 was 0.15 to 0.3 microgram/ml for 24 h o...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Yamamoto, T, Amitani, R, Suzuki, K, Tanaka, E, Murayama, T, Kuze, F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163127/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8834891/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.2.426
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