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Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex
SMG6 and SMG5 are essential factors in nonsense-mediated mRNA decay, a conserved pathway that degrades mRNAs with premature translation termination codons. Both SMG5 and SMG6 have been predicted to contain a C-terminal PIN (PilT N-terminus) domain, present in proteins with ribonuclease activity. We...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1630413/ https://ncbi.nlm.nih.gov/pubmed/17053788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601377 |
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