Evaluation of potent inhibitors of dihydrofolate reductase in a culture model for growth of Pneumocystis carinii.

Many antifolates are known to inhibit dihydrofolate reductase from murine Pneumocystis carinii, with 50% inhibitory concentrations (IC50s) ranging from 10(-4) to 10(-11) M. The relationship of the potency against isolated enzyme to the potency against intact murine P. carinii cells was explored with...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Bartlett, M S, Shaw, M, Navaran, P, Smith, J W, Queener, S F
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1995
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC162961/
https://ncbi.nlm.nih.gov/pubmed/8585722
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi