Expression of Streptomyces peucetius genes for doxorubicin resistance and aklavinone 11-hydroxylase in Streptomyces galilaeus ATCC 31133 and production of a hybrid aclacinomycin.

The aklavinone 11-hydroxylase gene and two doxorubicin resistance genes cloned from Streptomyces peucetius subsp. caesius ATCC 27952 were introduced into doxorubicin-sensitive Streptomyces galilaeus ATCC 31133, an aclacinomycin producer. The doxorubicin resistance genes drrA and drrB endowed S. gali...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Hwang, C K, Kim, H S, Hong, Y S, Kim, Y H, Hong, S K, Kim, S J, Lee, J J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162794/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7492117/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.7.1616
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