Cross-resistance to polyene and azole drugs in Cryptococcus neoformans.
Fluconazole was observed to inhibit sterol 14 alpha-demethylase in the human pathogen Cryptococcus neoformans, and accumulation of a ketosteroid product was associated with growth arrest. A novel mechanism(s) of azole and amphotericin B cross-resistance was identified, unrelated to changes in sterol...
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| Publié dans: | Antimicrob Agents Chemother |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
1995
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162775/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7492098/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.7.1526 |
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