Cross-resistance to polyene and azole drugs in Cryptococcus neoformans.

Fluconazole was observed to inhibit sterol 14 alpha-demethylase in the human pathogen Cryptococcus neoformans, and accumulation of a ketosteroid product was associated with growth arrest. A novel mechanism(s) of azole and amphotericin B cross-resistance was identified, unrelated to changes in sterol...

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izdano v:	Antimicrob Agents Chemother
Principais autores:	Joseph-Horne, T, Hollomon, D, Loeffler, R S, Kelly, S L
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1995
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162775/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7492098/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.7.1526
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