Potent antiviral activity of an antisense oligonucleotide complementary to the intron-exon boundary of human cytomegalovirus genes UL36 and UL37.

An antisense phosphorothioate oligonucleotide complementary to the intron-exon boundary of human cytomegalovirus genes UL36 and UL37 (UL36ANTI) reduced the yield of infectious virus by 99% and inhibited human cytomegalovirus DNA replication at a concentration of 0.08 microM. In addition, oligonucleo...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Pari, G S, Field, A K, Smith, J A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162700/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7625805/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.5.1157
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