Efficacies of ABT-719 and related 2-pyridones, members of a new class of antibacterial agents, against experimental bacterial infections.

The 2-pyridones are a new class of broad-spectrum orally bioavailable antibacterial agents. These compounds are potent bacterial DNA gyrase inhibitors which differ from fluoroquinolones by placement of the nitrogen atom in the ring juncture. ABT-719 is an S isomer and a representative 2-pyridone. AB...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Alder, J, Clement, J, Meulbroek, J, Shipkowitz, N, Mitten, M, Jarvis, K, Oleksijew, A, Hutch, T, Paige, L, Flamm, B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162663/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7786005/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.4.971
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