Organophosphate Insecticides Target the Serotonergic System in Developing Rat Brain Regions: Disparate Effects of Diazinon and Parathion at Doses Spanning the Threshold for Cholinesterase Inhibition

BACKGROUND: In the developing brain, serotonin (5HT) systems are among the most sensitive to disruption by organophosphates. OBJECTIVES: We exposed neonatal rats to daily doses of diazinon or parathion on postnatal days (PND)1–4 and evaluated 5HT receptors and the 5HT transporter in brainstem and fo...

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Main Authors: Slotkin, Theodore A., Tate, Charlotte A., Ryde, Ian T., Levin, Edward D., Seidler, Frederic J.
Format: Artigo
Jezik:Inglês
Izdano: National Institute of Environmental Health Sciences 2006
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1626396/
https://ncbi.nlm.nih.gov/pubmed/17035140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.9337
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