Potent induction of long-term CD8(+) T cell memory by short-term IL-4 exposure during T cell receptor stimulation

An important goal of vaccination is to achieve long-term survival of functional memory T cells. Using a MHC-compatible adoptive transfer system, we show here that a short, 3-day IL-4 but not IL-2 or IL-12 exposure during in vitro T cell receptor stimulation of naive CD8(+) T cells induced long-lasti...

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Detalhes bibliográficos
Main Authors: Huang, Li-Rung, Chen, Fen-Ling, Chen, Yi-Ting, Lin, Ya-Min, Kung, John T.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16252/
https://ncbi.nlm.nih.gov/pubmed/10725381
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