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A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance
Hemiasterlin is a potent antimitotic peptide that interferes with microtubule dynamics at picomolar concentrations in cell culture. The molecule largely eludes P glycoprotein-mediated drug efflux, and an analog is currently being evaluated in clinical trials as cancer chemotherapy. From a nonclonal...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1622856/ https://ncbi.nlm.nih.gov/pubmed/17032754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607338103 |
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