Targeted Disruption of the Mouse Rho-Associated Kinase 2 Gene Results in Intrauterine Growth Retardation and Fetal Death

Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. However, in vivo functions of each ROCK isoform remain largely unknown. We generated mice deficient in ROCK-II by gene targeting. ROCK-II(−/−) embryos we...

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Autores principales: Thumkeo, Dean, Keel, Jeongsin, Ishizaki, Toshimasa, Hirose, Masaya, Nonomura, Kimiko, Oshima, Hiroko, Oshima, Masanobu, Taketo, Makoto M., Narumiya, Shuh
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC162229/
https://ncbi.nlm.nih.gov/pubmed/12832488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.14.5043-5055.2003
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