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Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

Genetic evidence is mounting that survivin plays a crucial role in mitosis, but its exact role in human cell division remains elusive. We show that mammalian cells lacking survivin are unable to align their chromosomes, fail to recruit Aurora B to kinetochores and become polyploid at a very high fre...

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Udgivet i:EMBO J
Principais autores: Lens, Susanne M.A., Wolthuis, Rob M.F., Klompmaker, Rob, Kauw, Jos, Agami, Reuven, Brummelkamp, Thijn, Kops, Geert, Medema, René H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2003
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162159/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12805209/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg307
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