Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease

Negative feedback regulation of the proopiomelanocortin (POMC) gene by the glucocorticoid (Gc) receptor (GR) is a critical feature of the hypothalamo–pituitary–adrenal axis, and it is in part exerted by trans-repression between GR and the orphan nuclear receptors related to NGFI-B. We now show that...

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Hlavní autoři: Bilodeau, Steve, Vallette-Kasic, Sophie, Gauthier, Yves, Figarella-Branger, Dominique, Brue, Thierry, Berthelet, France, Lacroix, André, Batista, Dalia, Stratakis, Constantine, Hanson, Jeanette, Meij, Björn, Drouin, Jacques
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2006
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1619949/
https://ncbi.nlm.nih.gov/pubmed/17043312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1444606
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