Deficiency of Rbbp1/Arid4a and Rbbp1l1/Arid4b alters epigenetic modifications and suppresses an imprinting defect in the PWS/AS domain

Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are caused by deficiency of imprinted gene expression from paternal or maternal chromosome 15q11–q13, respectively. Genomic imprinting of the PWS/AS domain is regulated through a bipartite cis-acting imprinting center (PWS-IC/AS-IC) within and u...

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Bibliographic Details
Main Authors: Wu, Mei-Yi, Tsai, Ting-Fen, Beaudet, Arthur L.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2006
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1619944/
https://ncbi.nlm.nih.gov/pubmed/17043311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1452206
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