Structure-Based Mutagenesis of Herpes Simplex Virus Glycoprotein D Defines Three Critical Regions at the gD-HveA/HVEM Binding Interface

Herpes simplex virus (HSV) entry into cells requires the binding of glycoprotein D (gD) to one of several cell surface receptors. The crystal structure of gD bound to one of these receptors, HveA/HVEM, reveals that the core of gD comprises an immunoglobulin fold flanked by a long C-terminal extensio...

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Detalhes bibliográficos
Main Authors: Connolly, Sarah A., Landsburg, Daniel J., Carfi, Andrea, Wiley, Don C., Cohen, Gary H., Eisenberg, Roselyn J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC161942/
https://ncbi.nlm.nih.gov/pubmed/12829851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.14.8127-8140.2003
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