Role of Cks1 Overexpression in Oral Squamous Cell Carcinomas : Cooperation with Skp2 in Promoting p27 Degradation

Down-regulation of p27 is frequently observed in various cancers due to an enhancement of its degradation. Skp2 is required for the ubiquitination and consequent degradation of p27 protein. Another protein called Cks1 is also required for p27 ubiquitination in the SCF(Skp2) ubiquitinating machinery....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kitajima, Shojiro, Kudo, Yasusei, Ogawa, Ikuko, Bashir, Tarig, Kitagawa, Masae, Miyauchi, Mutsumi, Pagano, Michele, Takata, Takashi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Investigative Pathology 2004
Gaiak:
Original Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618711/
https://ncbi.nlm.nih.gov/pubmed/15579456
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