Interleukin-18 Promotes Joint Inflammation and Induces Interleukin-1-Driven Cartilage Destruction

Interleukin (IL)-18 is a member of the IL-1 family of proteins that exerts proinflammatory effects and is a pivotal cytokine for the development of Th1 responses. The goal of the present study was to investigate whether IL-18 induces joint inflammation and joint destruction directly or via induction...

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Autors principals: Joosten, Leo A.B., Smeets, Ruben L., Koenders, Marije I., van den Bersselaar, Liduine A.M., Helsen, Monique M.A., Oppers-Walgreen, Birgitte, Lubberts, Erik, Iwakura, Yoichiro, van de Loo, Fons A.J., van den Berg, Wim B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2004
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Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618596/
https://ncbi.nlm.nih.gov/pubmed/15331419
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