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Cerebral Expression of Interleukin-12 Induces Neurological Disease via Differential Pathways and Recruits Antigen-Specific T Cells in Virus-Infected Mice

Transgenic expression of interleukin-12 (IL-12) in astrocytes causes a spontaneous inflammatory central nervous system disorder in aged mice. Here we show that spontaneous disorder developed only when both mature lymphocytes and interferon (IFN)-γ were present. Infection with noncytolytic Borna dise...

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Bibliografische gegevens
Hoofdauteurs: Hofer, Markus, Hausmann, Jürgen, Staeheli, Peter, Pagenstecher, Axel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Investigative Pathology 2004
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618590/
https://ncbi.nlm.nih.gov/pubmed/15331418
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