Functional Defects in the Fanconi Anemia Pathway in Pancreatic Cancer Cells

Biallelic BRCA2-mutations can cause Fanconi anemia and are found in ∼7% of pancreatic cancers. Recently, several sequence changes in FANCC and FANCG were reported in pancreatic cancer. Functional defects in the Fanconi pathway can result in a marked hypersensitivity to interstrand crosslinking agent...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Van der Heijden, Michiel S., Brody, Jonathan R., Gallmeier, Eike, Cunningham, Steven C., Dezentje, David A., Shen, Dong, Hruban, Ralph H., Kern, Scott E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Investigative Pathology 2004
Gaiak:
Regular Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618568/
https://ncbi.nlm.nih.gov/pubmed/15277238
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